Kidney transplants are very successful for most people. A kidney from a living donor, on average, can last up to 18 years. A kidney from a deceased donor, on average, can last up to 12 years. Taking your medications as prescribed, attending regular appointments and following healthy habits all contribute to long-term success.
What is rejection?
Rejection happens when your immune system identifies your new kidney as foreign and tries to attack it. This is why immunosuppressive medications are so important — they help prevent this.
Types of rejection
There are different types of rejection, including:
Acute rejection
Can happen at any time but is most common in the first year. It may or may not cause symptoms and is often found through routine blood tests.
Chronic rejection
Occurs slowly over time and may eventually reduce kidney function.
Signs of possible rejection
- Fever of 38°C or greater (100.4 F or higher).
- Flu-like symptoms.
- Decreased urine output (peeing less) or darker urine.
- Blood in urine.
- Swelling in your legs or around your eyes.
- Shortness of breath.
- Pain or tenderness over your transplant.
- Sudden weight gain.
- High blood pressure.
- High creatinine levels.
Don’t panic over minor fluctuations
It’s normal for your blood test results (like creatinine) to fluctuate slightly. Many things — including hydration, medications or lab timing — can affect your numbers. The transplant team will help determine if a change is concerning or just routine.
Options to treat rejection
Early detection and intervention can often manage rejection effectively, helping preserve kidney function and avoid complications. That’s why it’s so important to keep taking your medications and attend all scheduled appointments. Make sure you always have a supply of your medicines. Bring a list of your medications, or your container to the clinic visit to make sure you have enough medication until your next clinic visit.
Rejection can be emotionally difficult and may bring up fear, sadness or grief. These feelings are valid. Please talk to us if you're struggling. Our social worker is available to support you.