{"id":3880,"date":"2016-05-18T13:48:12","date_gmt":"2016-05-18T17:48:12","guid":{"rendered":"http:\/\/52.229.122.34\/en\/?p=3880"},"modified":"2021-02-17T11:19:49","modified_gmt":"2021-02-17T16:19:49","slug":"immunotherapy-harnesses-our-own-immune-system-to-fight-cancer","status":"publish","type":"post","link":"https:\/\/www.ottawahospital.on.ca\/en\/uncategorized\/immunotherapy-harnesses-our-own-immune-system-to-fight-cancer\/","title":{"rendered":"Immunotherapy harnesses our own immune system to fight cancer"},"content":{"rendered":"

Ed Williams (left) didn\u2019t expect to live more than six months after his skin cancer spread to his brain. But nearly three years later, he is alive and well thanks to immunotherapy. Michelle Renaud (right) is one of the registered nurses who administers his treatment every two weeks as part of a clinical trial.<\/em><\/p>\n

It all started in 2011 with a new mole on his back. Within a few months, Ed Williams, then 47, was diagnosed with advanced melanoma. Despite the best available treatments, his cancer kept spreading, and he was told that his only option was to participate in a clinical trial of an experimental new therapy.<\/p>\n

\u201cI got into that trial the very last week it was open,\u201d said Williams, a former high-school teacher from Russell, Ontario. \u201cI almost didn\u2019t qualify because my cancer had spread to my brain, but the doctors and nurses at The Ottawa Hospital never gave up on me. I received cyberknife radiation treatment for my brain, and then I was able to get into that trial right before it closed.\u201d<\/p>\n

The trial, led at The Ottawa Hospital by oncologist Dr. Xinni Song, was evaluating a new class of therapy called immunotherapy. Rather than killing cancer cells directly, immunotherapy aims to harness the body\u2019s own immune system to fight cancer.<\/p>\n

\u201cOur immune system contains an army of cells which are our body\u2019s natural defences,\u201d explained Dr. Song, who is also an assistant professor at the University of Ottawa. \u201cThese cells are constantly on the lookout for cancer cells, but some cancers develop strategies to put the immune cells to sleep. The goal of this trial was to test new immunotherapy that enhances the body\u2019s immune reaction, or basically wakes up the immune cells so they can recognize and eliminate cancer cells.\u201d<\/p>\n

Soon after starting the trial, the tumours in Williams\u2019 lungs began to shrink. More than two years later, his cancer remains under control with biweekly treatment.<\/p>\n

\u201cCancer has become a chronic disease for me,\u201d said Williams. \u201cI\u2019m thankful for every day I have with my family.\u201d<\/p>\n

According to Dr. Song, immunotherapies like the one Williams received are revolutionizing treatment for melanoma and several other types of cancer.<\/p>\n

\u201cHistorically, the one-year survival rate for advanced melanoma was about 25 percent, but with these new immunotherapies, we\u2019re at about 70 to 80 percent,\u201d she said. \u201cWe\u2019re now doing trials with other immunotherapy combinations and to see if they will work in many other cancers as well.\u201d<\/p>\n

Researchers at The Ottawa Hospital are also looking at other approaches to stimulate the immune system to attack cancer cells, including viruses.<\/p>\n

\u201cWe\u2019re entering a new era of immuno-oncology, but this is just the beginning,\u201d said Dr. Song. \u201cWe need more research to figure out the best treatment strategies to improve efficacy and reduce toxicity, and to give our patients access to these exciting new therapies.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

Ed Williams (left) didn\u2019t expect to live more than six months after his skin cancer spread to his brain. But nearly three years later, he is alive and well thanks to immunotherapy. Michelle Renaud (right) is one of the registered nurses who administers his treatment every two weeks as part of a clinical trial. It […]<\/p>\n","protected":false},"author":25,"featured_media":3881,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3880","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"wps_subtitle":"","_links":{"self":[{"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/posts\/3880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/comments?post=3880"}],"version-history":[{"count":0,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/posts\/3880\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/media\/3881"}],"wp:attachment":[{"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/media?parent=3880"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/categories?post=3880"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/tags?post=3880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}