{"id":35920,"date":"2018-03-21T10:11:43","date_gmt":"2018-03-21T14:11:43","guid":{"rendered":"http:\/\/www.ottawahospital.on.ca\/?p=35920"},"modified":"2021-05-26T14:42:14","modified_gmt":"2021-05-26T18:42:14","slug":"two-miracles-in-one-lifetime-ms-clinical-trial-gave-heather-harris-back-more-than-her-life","status":"publish","type":"post","link":"https:\/\/www.ottawahospital.on.ca\/en\/healthy-tomorrows\/two-miracles-in-one-lifetime-ms-clinical-trial-gave-heather-harris-back-more-than-her-life\/","title":{"rendered":"Two miracles in one lifetime: MS clinical trial gave Heather Harris back more than her life"},"content":{"rendered":"

\u201cAfter the treatment, I never had another attack. I just started to feel better, and totally recovered,\u201d Heather Harris said about her stem cell transplant in 2006.<\/em><\/p>\n

Heather Harris was driving her fianc\u00e9 to a golf tournament one morning in 2001 when her right foot went numb. By the end of the day, the numbness had spread up the entire right side of her body.The<\/p>\n

then-24-year-old Thunder Bay resident had an MRI, which showed signs of multiple sclerosis (MS). The numbness was her first MS attack.<\/p>\n

MS is a devastating disease that occurs when the immune system \u2013 which protects against foreign organisms such as viruses or bacteria \u2013 mistakenly attacks the body\u2019s own central nervous system, which includes the brain, spinal cord, and optic nerve. Symptoms can range from blurred vision to extreme fatigue to complete paralysis.<\/p>\n

Harris needed to see a neurologist, but there were none near her home in Thunder Bay. Her parents lived in Ottawa and had heard about neurologist and MS specialist Dr. Mark Freedman. Dr. Freedman and Scientist Dr. Harold Atkins were leading a world-first clinical trial for MS at The Ottawa Hospital. The trial was investigating whether patients with early, aggressive MS would benefit if their immune system was wiped out with chemotherapy and then regenerated with blood stem cells. The study was showing great success. One trial patient, Jennifer Molson, was featured in the Ottawa Citizen<\/em> because she no longer exhibited any signs of MS and had recovered from damage already caused by the disease.<\/p>\n

\"Image

Heather Harris suffered several MS attacks a year before her stem cell transplant in November 2006.<\/p><\/div>\n

Harris got an appointment with Dr. Freedman at The Ottawa Hospital a few weeks before her wedding; he confirmed that Harris had MS. \u00a0When she asked about undergoing the same treatment as Jennifer Molson, he said: \u201cYou don\u2019t want to have to do that. That is for patients with a very poor prognosis, and it\u2019s difficult to determine if you are in that category yet.\u201d Dr. Freedman wanted to try regular treatments that were much less toxic and life-threatening than the stem cell transplant, since the chemotherapy could cause sterility.<\/p>\n

Unfortunately, it turned out that Harris was in the category of \u2018poor prognosis.\u2019 She suffered several MS attacks a year. Within a short time, she and her husband stopped canoe-camping because Harris had trouble even carrying a life jacket. She could no longer work the clutch to drive her manual-transmission car. Harris worked in a garden centre but her dream of having her own greenhouse vanished, as it became increasingly difficult to do the physical work. She decided to become a teacher. Her MS got worse while in teacher\u2019s college, and she managed to teach for only two years. Several times, she lost vision in one eye. Even walking became difficult.<\/p>\n

Harris\u2019 disease was progressing rapidly. Dr. Freedman told her she would be in a wheelchair within five years.<\/p>\n

\u201cTypical of MS, it affects young women in the prime of their lives,\u201d said Dr. Freedman. \u201cIt was a daunting problem with Heather living way up in Thunder Bay. With no specialists there, she had to be transferred down to The Ottawa Hospital for treatments. We tried some treatments, but she had an uncontrolled disease and things were advancing quickly. After it was clear we weren\u2019t going to control the disease with medicine, a stem cell transplant was her only option.\u201d<\/p>\n

Before Harris took part in the clinical trial, Dr. Freedman asked: \u201cHow important is it to you to have kids?\u201d She answered: \u201cIt is important, but not as important as it is to walk.\u201d<\/p>\n

\"Image

A decade after her stem cell transplant, Heather Harris is proud of her second \u2018miracle\u2019 \u2013 her daughter Zoe.<\/p><\/div>\n

\u201cDr. Freedman did a good job of trying to talk me out of the treatment, but this was my only chance to stop the disease,\u201d said Harris, who understood that the chemotherapy could cause sterility.<\/p>\n

Harris and her husband moved to Ottawa for a year while she took part in the trial. She had the stem cell transplant in November 2006.<\/p>\n

\u201cIt was pretty brutal, but I had such good care. Everyone at The Ottawa Hospital \u2013 the nurses and staff \u2013 were all amazing,\u201d she said. \u201cAfter the treatment, I never had another attack. I just started to feel better, and totally recovered.\u201d<\/p>\n

Harris, who now works full-time as a school principal, is back to camping, skiing, running and driving a manual car.<\/p>\n

\u201cIt\u2019s now 11 years since my stem cell transplant,\u201d said Harris. \u201cI really feel like I\u2019m cured.\u201d<\/p>\n

However, Harris and her husband wanted to have a baby. A nurse at The Ottawa Hospital suggested that it could be possible with in vitro fertilization. Harris underwent fertility treatments and in 2014 had a baby. Her daughter Zoe is now four years old.<\/p>\n

\"Image

Heather Harris and her husband, Shawn Mizon, celebrated with their daughter Zoe at a friend\u2019s wedding in September 2014.<\/p><\/div>\n

\u201cA couple of years ago, Heather showed up for her appointment with this little baby. It brought me to tears,\u201d said Dr. Freedman.<\/p>\n

\u201cI\u2019ve kind of had two miracles. I am so lucky and incredibly grateful,\u201d said Harris.<\/p>\n

In June 2016, Drs. Freedman and Atkins published the results of their clinical trial in The Lancet<\/em><\/a>, a top medical journal. The 24 patients who took part in the trial were followed for up to 13 years. To date, more than 50 MS patients from all over Canada have undergone this treatment, which eliminated all signs of damaging active brain inflammation. Two other sites in Canada \u2013 Calgary and Montreal \u2013 are now using the treatment developed at The Ottawa Hospital with the same positive, life-changing results.<\/p>\n

\u201cI have always been struck by the courage of the patients in this trial,\u201d said Dr. Atkins. \u201cWe knew a lot about potential side effects and while we thought it would be effective, we were not 100 percent certain whether this would work. Rather than seeing these young people robbed by the ravages of MS, it is exciting to see them get back to their lives.\u201d<\/p>\n

MS research at The Ottawa Hospital is supported by generous donations (opens in a new tab)<\/span><\/a> to The Ottawa Hospital Foundation, as well as organizations such as the MS Society of Canada.<\/p>\n","protected":false},"excerpt":{"rendered":"

One morning in 2001, Heather Harris\u2019 right foot went numb and then the numbness spread up her entire right side. This first multiple sclerosis attack led to her taking part in a clinical trial at The Ottawa Hospital that virtually eliminated her disease, yet she was still able to give birth to a healthy baby girl.<\/p>\n","protected":false},"author":25,"featured_media":35915,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[281,425],"class_list":["post-35920","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-healthy-tomorrows","tag-clinical-trials","tag-immunology"],"acf":[],"wps_subtitle":"","_links":{"self":[{"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/posts\/35920","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/comments?post=35920"}],"version-history":[{"count":0,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/posts\/35920\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/media\/35915"}],"wp:attachment":[{"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/media?parent=35920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/categories?post=35920"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/tags?post=35920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}