{"id":26062,"date":"2017-05-17T10:02:28","date_gmt":"2017-05-17T14:02:28","guid":{"rendered":"http:\/\/toh.wpengine.com\/en\/?p=26062"},"modified":"2020-09-25T16:01:45","modified_gmt":"2020-09-25T20:01:45","slug":"sprott-centre-for-stem-cell-research-celebrates-10-years-of-discovery","status":"publish","type":"post","link":"https:\/\/www.ottawahospital.on.ca\/en\/healthy-tomorrows\/sprott-centre-for-stem-cell-research-celebrates-10-years-of-discovery\/","title":{"rendered":"Sprott Centre for Stem Cell Research celebrates 10 years of discovery"},"content":{"rendered":"<div id=\"blogText\">\n<p align=\"center\"><em>The Ottawa Hospital has become a world leader in stem cell research.<\/em><\/p>\n<p>Bringing stem cell research to patients \u2013 that\u2019s the common goal that has united research specialists from a wide range of disciplines under The Ottawa Hospital\u2019s Sprott Centre for Stem Cell Research.<\/p>\n<p>Over the past 10 years, the centre has become the hub of the world-renowned group of researchers who make up the hospital\u2019s <a href=\"https:\/\/www.ohri.ca\/programs\/regenerative_medicine\/default.asp\" target=\"_blank\" rel=\"noopener noreferrer\">Regenerative Medicine Program<\/a>.<\/p>\n<p>\u201cWe are entering a new era of medicine,\u201d said Dr. <a href=\"https:\/\/www.ohri.ca\/profile\/mrudnicki\/profile\" target=\"_blank\" rel=\"noopener noreferrer\">Michael Rudnicki<\/a>, Director and senior scientist at the Sprott Centre and professor at the University of Ottawa. \u201cMore and more we are going to see regenerative medicine using cutting-edge disruptive technologies to treat many devastating diseases that have no current therapy. With the expertise we have built in Ottawa, we are leading the way with significant discoveries and their translation to the clinic.\u201d<\/p>\n<p>The Sprott Centre supports the work of stem cell researchers with facilities that can analyze cells\u2019 proteins and genetic profile. It also has clean rooms used to manufacture cells for early stage clinical trials.<\/p>\n<p>Discoveries from the Sprott Centre have led to several first-in-human clinical trials and the creation of several biotechnology companies. Some of these discoveries include:<\/p>\n<ul>\n<li>Dr. <a href=\"https:\/\/www.ohri.ca\/profile\/mrudnicki\/profile\" target=\"_blank\" rel=\"noopener noreferrer\">Michael Rudnicki<\/a> discovered stem cells in adult muscle. His work has opened the door to developing drugs to help repair muscles in patients with muscular dystrophy.<\/li>\n<li>Dr.<a href=\"https:\/\/www.ohri.ca\/profile\/Brand_Lab\" target=\"_blank\" rel=\"noopener noreferrer\">Marjorie Brand<\/a> showed that blood vessel stem cells grown in the lab can be encouraged to repair blood vessels more quickly after transplantation in a patient if they are treated with drugs that turn genes on and off. She is exploring which molecular pathways to target to further optimize this process.<\/li>\n<li>Dr. <a href=\"https:\/\/www.ohri.ca\/profile\/F_Jeffrey_Dilworth\" target=\"_blank\" rel=\"noopener noreferrer\">Jeffrey Dilworth<\/a> identified several key proteins needed to control the conversion of muscle stem cells into mature muscle. He is looking at how this could be used to treat different muscle-wasting diseases.<\/li>\n<li>Dr. <a href=\"https:\/\/www.ohri.ca\/profile\/lmegeney\" target=\"_blank\" rel=\"noopener noreferrer\">Lynn Megeney<\/a> demonstrated that scissor-like proteins normally involved in cell death play a key role in converting muscle stem cells into mature muscle. He is exploring how drugs that block the scissor-like function of these proteins can be used to improve muscle regeneration.<\/li>\n<li>Dr. <a href=\"https:\/\/www.ohri.ca\/profile\/wstanford\" target=\"_blank\" rel=\"noopener noreferrer\">William Stanford<\/a> re-programmed connective tissue cells from patients with Progeria, a genetic condition that causes rapid premature aging, into a kind of stem cell that gives rise to any type of cell in the body. His work helps us better understand how our cells change during aging, and how they might be rejuvenated.<\/li>\n<\/ul>\n<p>The Ottawa Hospital\u2019s leadership in stem cell research promises even more discoveries in the decades to come.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Bringing stem cell research to patients \u2013 that\u2019s the common goal that has united research specialists from a wide range of disciplines under The Ottawa Hospital\u2019s Sprott Centre for Stem Cell Research, now celebrating its 10th anniversary.<\/p>\n","protected":false},"author":25,"featured_media":26063,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[281,402,92,93],"class_list":["post-26062","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-healthy-tomorrows","tag-clinical-trials","tag-leadership","tag-research","tag-stem-cells"],"acf":[],"wps_subtitle":"","_links":{"self":[{"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/posts\/26062","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/comments?post=26062"}],"version-history":[{"count":0,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/posts\/26062\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/media\/26063"}],"wp:attachment":[{"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/media?parent=26062"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/categories?post=26062"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ottawahospital.on.ca\/en\/wp-json\/wp\/v2\/tags?post=26062"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}